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Therapeutic angiogenesis and vasculogenesis for tissue regeneration

Madeddu, Paolo Roberto (2005) Therapeutic angiogenesis and vasculogenesis for tissue regeneration. Experimental Physiology, Vol. 90 (3), p. 315-326. eISSN 1469-445X. Article.

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DOI: 10.1113/expphysiol.2004.028571

Abstract

Therapeutic angiogenesis/vasculogenesis holds promise for the cure of ischaemic disease. The approach postulates the manipulation of spontaneous healing response by supplementation of growth factors or transplantation of vascular progenitor cells. These supplements are intended to foster the formation of arterial collaterals and promote the regeneration of damaged tissues. Angiogenic factors are generally delivered in the form of recombinant proteins or by gene transfer using viral vectors. In addition, new non-viral methods are gaining importance for their safer profile. The association of growth factors with different biological activity might offer distinct advantages in terms of efficacy, yet combined approaches require further optimization. Alternatively, substances with pleiotropic activity might be considered, by virtue of their ability to target multiple mechanisms. For instance, some angiogenic factors not only stimulate the growth of arterioles and capillaries, but also inhibit vascular destabilization triggered by metabolic and oxidative stress. Transplantation of endothelial progenitor cells was recently proposed for the treatment of peripheral and myocardial ischaemia. Progenitor cells can be transplanted either without any preliminary conditioning or after ex vivo genetic manipulation. Delivery of genetically modified progenitor cells eliminates the drawback of immune response against viral vectors and makes feasible repeating the therapeutic procedure in case of injury recurrence. It is envisioned that these new approaches of regenerative medicine will open unprecedented opportunities for the care of life-threatening diseases.

Item Type:Article
ID Code:1320
Status:Published
Refereed:Yes
Uncontrolled Keywords:Angiogenesis, vascular progenitor cells, ischaemic disease, tissue regeneration
Subjects:Area 06 - Scienze mediche > MED/11 Malattie dell'apparato cardiovascolare
Divisions:001 Università di Sassari > 03 Istituti > Clinica medica generale e terapia medica
002 Altri enti e centri di ricerca del Nord Sardegna > National laboratory of the national institute of biostructures and biosystems, Osilo
Publisher:Blackwell / Wiley
eISSN:1469-445X
Copyright Holders:© The Physiological Society
Additional Information:Pubblicato online il 18 marzo 2005.
Deposited On:18 Aug 2009 10:04

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