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Detection of Chlamydiae pneumoniae but not Helicobacter pylori DNA in atherosclerosis plaques

Dore, Maria Pina and Sepulveda, Antonia R. and Bacciu, Piero Paolo and Blasi, Francesco and Simula, Luigi and Marras, Lea and Piccolo, Davide and Cherchi, Giovanni Battista and Graham, David Y. and Realdi, Giuseppe (2003) Detection of Chlamydiae pneumoniae but not Helicobacter pylori DNA in atherosclerosis plaques. Digestive Diseases and Sciences, Vol. 48 (5), p. 945-951. eISSN 1573-2568. Article.

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DOI: 10.1023/A:1023059815117


Chronic infections have been associated with cardiovascular disease. We used bacterial culture, polymerase chain reaction (PCR), and immunohistochemical staining with anti-vacA and anticagA antibodies to search for Helicobacter pylori and Chlamydiae pneumoniae in atherosclerotic plaques obtained at endarterectomy. Serum IgG antibodies to H. pylori and C. pneumoniae were also determined. Thirty-two patients were enrolled. Anti-H. pylori and anti-C. pneumoniae IgG were present in 72% and 81%, respectively. Culture and PCR for H. pylori of vessel walls and plaques were negative. Atherosclerotic plaque and normal vessel sections from H. pylori-negative and- positive patients showed reactivity with anti-vacA and anti-cagA antibodies. C. pneumoniae DNA was amplified in three atherosclerotic lesions. These findings suggest that the association between H. pylor infection and atherosclerosis does not result from continuing direct effects of H. pylori antigens in the vessel walls. Antigens within vessel atherosclerotic plaques cross-react with H. pylori virulence factors and could act as cofactors in determining instability for the atherosclerotic plaques.

Item Type:Article
ID Code:1310
Uncontrolled Keywords:Helicobacter pylori infection, Chlamydiae pneumoniae, dyspepsia, atherosclerosis, mimicry
Subjects:Area 06 - Scienze mediche > MED/22 Chirurgia vascolare
Area 06 - Scienze mediche > MED/12 Gastroenterologia
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL1, Sassari > Ospedale civile SS. Annunziata
001 Università di Sassari > 03 Istituti > Clinica chirurgica generale e terapia chirurgica
Publisher:Springer Netherlands
Deposited On:18 Aug 2009 10:04

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