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A Novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells

Lee, Ju-Seog and Heo, Jeonghoon and Libbrecht, Louis and Chu, In-Sun and Kaposi-Novak, Pal and Calvisi, Diego Francesco and Mikaelyan, Arsen and Roberts, Lewis R. and Demetris, Anthony J. and Sun, Zongtang and Nevens, Frederik and Roskams, Tania and Thorgeirsson, Snorri S. (2006) A Novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nature Medicine, Vol. 12 (4), p. 410-416. eISSN 1546-170X. Article.

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DOI: 10.1038/nm1377


The variability in the prognosis of individuals with hepatocellular carcinoma (HCC) suggests that HCC may comprise several distinct biological phenotypes. These phenotypes may result from activation of different oncogenic pathways during tumorigenesis and/or from a different cell of origin. Here we address whether the transcriptional characteristics of HCC can provide insight into the cellular origin of the tumor. We integrated gene expression data from rat fetal hepatoblasts and adult hepatocytes with HCC from human and mouse models. Individuals with HCC who shared a gene expression pattern with fetal hepatoblasts had a poor prognosis. The gene expression program that distinguished this subtype from other types of HCC included markers of hepatic oval cells, suggesting that HCC of this subtype may arise from hepatic progenitor cells. Analyses of gene networks showed that activation of AP-1 transcription factors in this newly identified HCC subtype might have key roles in tumor development.

Item Type:Article
ID Code:1299
Uncontrolled Keywords:Hepatocellular carcinoma, biological phenotypes, oncogenic pathways, prognosis, hepatic oval cells, AP-1 transcription factors
Subjects:Area 06 - Scienze mediche > MED/04 Patologia generale
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Nature Publishing Group
Additional Information:Pubblicato online il 12 marzo 2006.
Deposited On:18 Aug 2009 10:04

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