Ali, Shaik Mahaboob and Khan, Aleem A. and Ahmed, Irshad and Musaddiq, M. and Ahmed, Khaja S. and Polasa, H. and Venkateswar Rao, L. and Habibullah, Chittoor M. and Sechi, Leonardo Antonio and Ahmed, Niyaz (2005) Antimicrobial activities of eugenol and cinnamaldehyde against the human gastric pathogen Helicobacter pylori. Annals of Clinical Microbiology and Antimicrobials, Vol. 4 (20), p. 1-7. ISSN 1476-0711. Article.
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Background: Eradication of Helicobacter pylori is an important objective in overcoming gastric
diseases. Many regimens are currently available but none of them could achieve 100% success in
eradication. Eugenol and cinnamaldehyde that are commonly used in various food preparations are
known to possess antimicrobial activity against a wide spectrum of bacteria.
Aim: The present study was performed to assess the in vitro effects of eugenol and cinnamaldehyde against indigenous and standard H. pylori strains, their minimum inhibitory concentrations (MICs) and time course lethal effects at various pH.
Methods: A total of 31 strains (29 indigenous and one standard strain of H. pylori ATCC 26695,
one strain of E. coli NCIM 2089) were screened. Agar dilution method was used for the
determination of drug sensitivity patterns of isolates to the commonly used antibiotics and broth
dilution method for the test compounds.
Results: Eugenol and cinnamaldehyde inhibited the growth of all the 30 H. pylori strains tested, at
a concentration of 2 μg/ml, in the 9th and 12th hours of incubation respectively. At acidic pH,
increased activity was observed for both the compounds. Furthermore, the organism did not
develop any resistance towards these compounds even after 10 passages grown at sub-inhibitory
Conclusion: These results indicate that the two bioactive compounds we tested may prevent H.
pylori growth in vitro, without acquiring any resistance.
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