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Y-chromosome specific YCAII, DYS19 and YAP polymorphisms in human populations: a comparative study

Quintana Murci, Lluìs and Semino, Ornella and Poloni, Estella and Liu, A. and Gijn, M. van and Passarino, Giuseppe and Brega, Agnese and Nasidze, Ivan and Maccioni, L. and Cossu, Gianfranco and Al-Zaheri, Nadia and Kidd, Judith R. and Kidd, Kenneth K. and Santachiara Benerecetti, Silvana Augusta (1999) Y-chromosome specific YCAII, DYS19 and YAP polymorphisms in human populations: a comparative study. Annals of Human Genetics, Vol. 63 (2), p. 153-166. eISSN 1469-1809. Article.

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DOI: 10.1046/j.1469-1809.1999.6320153.x


Two hypervariable Y-specific markers, the YCAII and DYS19 STRs, and the more stable Y Alu Polymorphism (YAP) have been analysed in about 1400 individuals of 21 different populations, mainly from Europe but also from the Middle East, Africa and Asia. On the basis of the frequency distributions of these three Y-markers we compare, using different statistical analyses, their power in detecting population genetic structure and in distinguishing closely related groups. The pattern of populations' genetic affinities inferred from the three markers considered altogether suggests a strong genetic structure that, with a few exceptions, broadly corresponds to the linguistic relatedness and/or geographic location of the sampled populations.

Item Type:Article
ID Code:1282
Uncontrolled Keywords:Y-chromosome, YAP polymorphisms, genetic diversity
Subjects:Area 06 - Scienze mediche > MED/03 Genetica medica
Area 05 - Scienze biologiche > BIO/18 Genetica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL1, Sassari > Ospedale "A. Segni", Ozieri > Centro trasfusionale
Publisher:Blackwell / Wiley
Copyright Holders:Journal compilation © 2009 Blackwell Publishing Ltd/University College London
Deposited On:18 Aug 2009 10:04

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