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A case-control study on a novel DNA virus (TT virus) infection and hepatocellular carcinoma

Tagger, Alessandro and Donato, Francesco and Ribero, Maria Luisa and Binelli, Giorgio and Gelatti, Umberto and Portera, Giuseppe and Albertini, Alberto and Fasola, Michele and Chiesa, Roberta and Nardi, Giuseppe (1999) A case-control study on a novel DNA virus (TT virus) infection and hepatocellular carcinoma. Hepatology, Vol. 30 (1), p. 294-299. eISSN 1527-3350. Article.

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DOI: 10.1002/hep.510300115


We performed a case-control study to evaluate the association of a new human DNA virus named TT virus (TTV) with hepatocellular carcinoma (HCC). We recruited 174 subjects hospitalized for HCC (84% males; mean age: 64 years) and 118 patients hospitalized for non-liver diseases in Brescia, northern Italy, as controls (94% males; mean age: 66 years). TTV DNA was found in serum by polymerase chain reaction (PCR) in 26 cases (15%) and 11 controls (9.3%) (P > .1). TTV group 2 infection was identified in 16 cases (61.5%) and 4 controls (36.4%) (P > .1) using a type-specific PCR method. Sequence analysis of 222 nt of TTV DNA demonstrated that the remaining 10 cases and 7 controls were all infected by group 1. The odds ratio (OR) for TTV-DNA positivity, adjusted for demographic variables, hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) RNA, and heavy alcohol intake was 1.8 (95% CI: 0.7-4.8; P > .1). The OR did not change when the analysis was restricted to 14 HCC cases and 56 controls who were negative for each known risk factor for HCC (OR = 1.7; 95% CI: 0.8-4.0). TTV-DNA positivity was not associated with transfusion history. The prevalence of TTV DNA was higher among HCC cases positive for HBsAg (10 of 38 [26.3%]) than among those positive for HCV RNA (8 of 62 [12.9%]) or negative for hepatitis B virus (HBV), HCV, and hepatitis G virus (HGV) infections (5 of 62 [8.1%]) (P = .02). This study does not support the hypothesis of an association between TTV infection and HCC.

Item Type:Article
ID Code:1270
Uncontrolled Keywords:Viral hepatitis, DNA virus, hepatocellular carcinoma, predictive factor, viral disease, malignant tumor
Subjects:Area 05 - Scienze biologiche > BIO/18 Genetica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze fisiologiche, biochimiche e cellulari
Copyright Holders:© 1999 by the American Association for the Study of Liver Diseases
Additional Information:Pubblicato online il 30 dicembre 2003.
Deposited On:18 Aug 2009 10:04

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