titoli, abstracts, parole chiave >>>
Sudden death in epilepsy: an experimental animal model

Becciu, Chiara Ombretta and Caria, Marcello Alessandro and Pintus, A. and Padua, Giovanni and Mameli, Stefano (2006) Sudden death in epilepsy: an experimental animal model. Seizure, Vol. 15 (5), p. 275-287. ISSN 1059-1311. Article.

Full text not available from this repository.

DOI: 10.1016/j.seizure.2006.02.007

Abstract

Introduction: The physiopathogenetic mechanisms possibly involved in sudden unexplained epileptic death (SUDEP), were investigated in the hemispherectomized rat. Methods: For this purpose, paroxysmal activity, vagal nerve firing, systemic blood pressure (BP), pulmonary artery pressure, and ECG were simultaneously recorded in an experimental animalmodel of epilepsy. Recordings were performed in basal conditions and during paroxysmal activity induced by topical application of penicillin-G at hypothalamic and mesencephalic level. During the experiment were also performed hemogas analysis and at end, samples of lung tissue were processed for histology. Results: Activation of hypothalamic (HEF) and mesencephalic (MEF) epileptic foci induced a significant increase of spontaneous vagal nerve firing that was strictly correlated to ECG impairments and hypotension. When paroxysmal activity extinguished, vagal nerve activity and cardiovascular parameters returned to basal conditions. However, in 25% of the animals, co-activation of HEF and MEF always triggered a vagal hypertone which was temporally correlated to cardiac arrhythmias, but also to hyperkalemia, acidosis, pulmonary hypertension and to animal death. Histological control in lungs of deceased animals showed an alveolar and perivessel oedema with an oedematous infiltration in the alveolar and bronchial spaces and mucous secretion. During ictal activity, comparison between survived and deceased animals showed significant differences in the incidence of ECG impairment of pulmonary artery pressures, pO2, and pCO2 pressures, and [K+], [HCO3], and [pH], concentrations. Discussion: A possible explanation of the above observations is discussed in relationship.

Item Type:Article
ID Code:1248
Status:Published
Refereed:Yes
Uncontrolled Keywords:Sudden epileptic death, cardioarrhythmogenic cerebral triggers, parasympathetic activity, cardiovascular parameters, lung histology, hemogas parameters
Subjects:Area 05 - Scienze biologiche > BIO/09 Fisiologia
Divisions:001 Università di Sassari > 03 Istituti > Anestesologia, rianimazione e terapia intensiva
001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Anatomia patologica
002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL3, Nuoro > Ospedale "San Francesco" > Unità di Terapia Intensiva Coronarica (UTIC)
Publisher:Elsevier
ISSN:1059-1311
Copyright Holders:© 2006 British Epilepsy Association
Deposited On:18 Aug 2009 10:04

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page