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Mycobacterium avium subspecies paratuberculosis is not associated with Type-2 diabetes mellitus

Rosu, Valentina and Ahmed, Niyaz and Paccagnini, Daniela and Pacifico, Adolfo and Zanetti, Stefania Anna Lucia and Sechi, Leonardo Antonio (2008) Mycobacterium aviumsubspecies paratuberculosis is not associated with Type-2 diabetes mellitus. Annals of Clinical Microbiology and Antimicrobials, Vol. 7 (9), p. 1-4. ISSN 1476-0711. Article.

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DOI: 10.1186/1476-0711-7-9


Background. The role of pathogenic mycobacteria in diabetes has been a focus of speculation since a decade without any meaningful insights into the mechanism of diabetes causation vis a vis mycobacterial factors. Two of our studies based on PCR identification of mycobacterial DNA and detection of antibodies specific to the recombinant antigens and whole cell lysates of the Mycobacterium avium subsp. paratuberculosis (MAP) shown a clear association of MAP with the presence of type 1 diabetes mellitus (T1DM).
Methods. In this study, we sought to investigate if or not type 2 diabetes (T2DM) patients harbour humoral responses to MAP. Using three different MAP antigen preparations, humoral antibody profiles were estimated for 57 T2DM patients and 57 healthy controls. Statistical analysis was performed with the Chi-square test with Yates' corrections.
Results. We observed insignificant levels of humoral antibodies against recombinant heparin binding haemagglutinin (HbHA), glycosyl transferase (Gsd) and MAP whole cell lysate in the blood of subjects with T2DM as compared to healthy controls.
Conclusion. We found no obvious association of MAP with the incidence of T2DM in Sardinian patients.

Item Type:Article
ID Code:124
Uncontrolled Keywords:Pathogenic mycobacteria, T2DM, MAP antigens, Sardinia
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 03 Istituti > Clinica medica generale e terapia medica
001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:BioMed Central
Copyright Holders:© 2008 Rosu et al; licensee BioMed Central
Deposited On:18 Aug 2009 10:01

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