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Autonomic nervous system activity and life threatening arrhythmias in experimental epilepsy

Becciu, Chiara Ombretta and Caria, Marcello Alessandro and Melis, Francesco and Severino, C. and Tavera, Claudio and Mameli, Piero and Mameli, S. (2001) Autonomic nervous system activity and life threatening arrhythmias in experimental epilepsy. Seizure, Vol. 10 (4), p. 269-278. ISSN 1059-1311. Article.

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DOI: 10.1053/seiz.2000.0509

Abstract

In the present study the possible derangement of the autonomic system and its influence in life threatening arrhythmias were analysed during paroxysmal activity. In hemispherectomized rats a paroxysmal activation of the hypothalamic and mesencephalic cardioarrhythmogenic triggers was performed by topical application of penicillin-G. Blood gas parameters and electrical activity of the thalamus, hypothalamus, vagal nerve fibre, ECG and arterial blood pressure were simultaneously monitored in basal conditions and repeated after the appearance of paroxysmal activity. Temporal correlation analysis was carried out. Results showed that during activation of these triggers, the spontaneous vagal nerve fibre activity significantly increased and triggered the appearance of cardiac arrhythmias which could become life threatening and induce animal death when blood gas and electrolytic parameters were simultaneously impaired. These experiments suggest that fatal evolution of the heart impairment is related not only to an autonomic cardiac trigger, but also to a concomitant metabolic derangement, which most likely shares the same autonomic origin.

Item Type:Article
ID Code:1226
Status:Published
Refereed:Yes
Uncontrolled Keywords:Experimental epilepsy, cardioarrhythmogenic triggers, autonomic nervous system, cardiac arrhythmias, blood gas and metabolic parameters, rat
Subjects:Area 05 - Scienze biologiche > BIO/09 Fisiologia
Divisions:001 Università di Sassari > 03 Istituti > Clinica medica generale e terapia medica
001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Elsevier
ISSN:1059-1311
Copyright Holders:© 2001 BEA Trading
Deposited On:18 Aug 2009 10:04

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