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Neurotoxic effect of lead at low concentrations

Becciu, Chiara Ombretta and Caria, Marcello Alessandro and Melis, Francesco and Tavera, Claudio and Ibba, Antonio and Tocco, Maria Giuseppina and Flore, Costantino and Sanna Randaccio, Francesco (2001) Neurotoxic effect of lead at low concentrations. Brain Research Bulletin, Vol. 55 (2), p. 269-275. ISSN 0361-9230. Article.

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DOI: 10.1016/S0361-9230(01)00467-1


The effects of lead exposure at low concentrations were evaluated by studying the post-rotatory nystagmus (PRN) in two groups of rats exposed for 3 months to 50 parts per million (ppm) of sodium acetate and 50 ppm of lead acetate, respectively, in the drinking water. Only animals treated with lead acetate showed changes of the PRN parameters which were significantly related to the concentration of lead in the blood and in brain structures. The patterns of PRN responses were characterized and classified into four types: progressively inhibitory (40%), prematurely inhibitory (25%), late inhibitory (25%), and excitatory-inhibitory (10%). No alterations of the PRN parameters were observed in the animals treated with sodium acetate. The results show that exposure to lead, even at low concentrations, impairs both sensory and motor functions. The findings also point out that the vestibular system and brain stem structures which generate and control the PRN represent targets of the action of this heavy metal. Finally, the results indicate that the evaluation of the vestibulo-ocular-reflex can provide a test suited for the screening of the neurotoxic effects of lead even in the absence of clinical signs typical of lead intoxication.

Item Type:Article
ID Code:1225
Uncontrolled Keywords:Vestibulo-ocular-reflex, post-rotatory-nystagmus, heavy metals, brainstem, rat
Subjects:Area 06 - Scienze mediche > MED/44 Medicina del lavoro
Area 05 - Scienze biologiche > BIO/09 Fisiologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Deposited On:18 Aug 2009 10:04

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