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Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat

Sechi, Gianpietro and De Riu, PierLuigi and Becciu, Chiara Ombretta and Deiana, Giovanni Andrea and Cocco, Giovanni Antonio and Rosati, Giulio (2003) Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat. Seizure, Vol. 12 (7), p. 508-515. ISSN 1059-1311. Article.

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DOI: 10.1016/S1059-1311(03)00053-0

Abstract

The objective of this study was to document the convulsant properties of thiocolchicoside in rats, and to characterise the electroclinical pattern of epileptic seizures. Experiments were carried out in three groups of male Wistar rats: in group A, thiocolchicoside was applied topically to the pia, or given by microinjection to the cerebral cortex (2 μg/μl); in group B, the drug was administered parenterally (6 mg/kg) to rats with minimal lesions of the dura and arachnoid membranes; in group C, thiocolchicoside was administered parenterally (up to 12 mg/kg) to intact rats. In all animals, electroclinical activity was continuously monitored for at least 3 hours after thiocolchicoside injection or application. In group A, electrographic and behavioural activity of focal motor seizures occurred in 100% of animals, developing into a focal status epilepticus; in group B, a multifocal epileptic pattern with secondary generalisation, clinically characterised by clonic or tonic–clonic seizures occurred in 100% of animals, until a secondarily generalised convulsive status epilepticus; in group C, none of animals showed either electrographic or behavioural seizure activity. Our study documents that thiocolchicoside has a powerful convulsant activity in the rat, perhaps due to an antagonistic interaction of the compound with a cortical subtype of the GABAA receptor.

Item Type:Article
ID Code:1221
Status:Published
Refereed:Yes
Uncontrolled Keywords:Thiocolchicoside, status epilepticus, GABAA receptors
Subjects:Area 05 - Scienze biologiche > BIO/09 Fisiologia
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Elsevier
ISSN:1059-1311
Copyright Holders:© 2003 BEA Trading
Deposited On:18 Aug 2009 10:04

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