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Effect of aluminum consumption on the vestibulo-ocular reflex

Becciu, Chiara Ombretta and Caria, Marcello Alessandro and Melis, Pietro and Zambenedetti, Pamela and Ramila, M. and Zatta, Paolo (2006) Effect of aluminum consumption on the vestibulo-ocular reflex. Metabolic Brain Disease, Vol. 21 (2-3), p. 86-104. eISSN 1573-7365. Article.

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DOI: 10.1007/s11011-006-9010-9


The effects of chronic exposure (90 days) to Aluminum chloride (AlCl3) were analyzed in 3, 10 and 24 month old male rats (n=270) by investigating the function of the VOR (vestibulo-ocular reflex) in correlation with Aluminum (Al) concentrations in blood and brain. The VOR was chosen and tested in basal conditions (pre-exposure measures) and during the continuous administration of three different concentrations of AlCl3 (0.5, 1, 2 g/l in drinking solution): the control animals being exposed to NaCl (0.125, 0.25 and 5 g/l in drinking solution). Results showed that LOAEL (Lowest Observed Adverse Effect Level) was 43.1±11.4 mg Al/kg-day. At this concentration the Al induced significant VOR impairment in all exposed rats, regardless of animal age. Neuroanatomical analysis showed that VOR impairment was not dependent on astrocyte damage nor evidences of amyloid deposits in the exposed rats was found. Significant changes of Al concentrations were observed in nervous tissue, while its concentration in whole blood was unaffected. Furthermore, results show that it is possible to identify an individual neurotoxic threshold for each animal and therefore hypothesize the clinical use of the VOR test for the evaluation of individual risk toxicity to chronic Al exposure.

Item Type:Article
ID Code:1220
Uncontrolled Keywords:Aluminum, nervous system, rat, vestibulo-ocular reflex, astrocyte, anti-GFAP, anti-MT I–II
Subjects:Area 05 - Scienze biologiche > BIO/09 Fisiologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Scienze ambientali agrarie e biotecnologie agro-alimentari
Publisher:Springer Netherlands
Copyright Holders:© Springer Science+Business Media, Inc. 2006
Deposited On:18 Aug 2009 10:04

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