UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
Effect of tetrazole moiety on coordinating efficiency of deltorphin

Lodyga-Chruscinska, Elzbieta and Oldziej, Stanislaw and Micera, Giovanni and Sanna, Daniele and Chruscinski, Longin and Olczak, Jacek and Zabrocki, Janusz (2004) Effect of tetrazole moiety on coordinating efficiency of deltorphin. Acta Biochimica Polonica, Vol. 51 (1), p. 93-106. ISSN 1734-154X. Article.

Full text not available from this repository.

Alternative URLs:

Abstract

A study of the effect of the tetrazole moiety, a cis-amide bond surrogate, on the Cu(II) coordinating properties of oligopeptides is reported. Insertion of the tetrazole moiety Ψ[CN4] into the peptide sequence of [D-Ala2]deltorphin I changes considerably the coordination ability of the peptide. Potentiometric and spectroscopic results show that if the tetrazole moiety is in a suitable position in the peptide chain, i.e. it follows the second residue, a stable CuL species involving 3N coordination is formed in the physiological pH range. The tetrazole Ψ[CN4] ring provides one of these nitrogens. The data indicate that Cu(II) ions are strongly trapped inside a bent peptide backbone. The peptide conformation changes achieved by Cu(II) coordination may be essential for the binding of tetrazole deltorphins at opiate receptors.

Item Type:Article
ID Code:1218
Status:Published
Refereed:Yes
Uncontrolled Keywords:Opiod peptides, tetrazole analogues of deltorphin I, Cu(II) complexes
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:Acta Biochimica Polonica
ISSN:1734-154X
Additional Information:Part of the results were presented at the 17. Polish Peptide Symposium, August 31-September 4, 2003, Lodz, Poland.
Deposited On:18 Aug 2009 10:04

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page