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Primary afferent plasticity following deafferentation of the trigeminal brainstem nuclei in the adult rat

De Riu, Pier Luigi and Russo, Antonella and Pelliteri, Rosalia and Stanzani, Stefania and Tringali, Giovanni and Roccazzello, Anna Maria and De Riu, Giacomo and Marongiu, Patrizia and Becciu, Chiara Ombretta (2008) Primary afferent plasticity following deafferentation of the trigeminal brainstem nuclei in the adult rat. Experimental Neurology, Vol. 213 (1), p. 101-107. ISSN 0014-4886. Article.

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DOI: 10.1016/j.expneurol.2008.05.010

Abstract

Alpha-tyrosinated tubulin is a cytoskeletal protein that is involved in axonal growth and is considered a marker of neuronal plasticity in adult mammals. In adult rats, unilateral ablation of the left facial sensorimotor cortical areas induces degeneration of corticotrigeminal projections and marked denervation of the contralateral sensory trigeminal nuclei. Western blotting and real-time-PCR of homogenates of the contralateral trigeminal ganglion (TG) revealed consistent overexpression of growth proteins 15 days after left decortication in comparison with the ipsilateral side. Immunohistochemical analyses indicated marked overexpression of α-tyrosinated tubulin in the cells of the ganglion on the right side. Cytoskeletal changes were primarily observed in the small ganglionic neurons. Application of HRP-CT, WGA-HRP, and HRP to infraorbital nerves on both sides 15 days after left decortication showed a significant degree of terminal sprouting and neosynaptogenesis from right primary afferents at the level of the right caudalis and interpolaris trigeminal subnuclei. These observations suggest that the adaptive response of TG neurons to central deafferentation, leading to overcrowding and rearrangement of the trigeminal primary afferent terminals on V spinal subnuclei neurons, could represent the anatomical basis for distortion of facial modalities, perceived as allodynia and hyperalgesia, despite nerve integrity.

Item Type:Article
ID Code:1217
Status:Published
Refereed:Yes
Uncontrolled Keywords:Trigeminal primary afferent plasticity, Alpha-tyrosinated tubulin expression, cortical deafferentation
Subjects:Area 06 - Scienze mediche > MED/29 Chirurgia maxillofacciale
Area 05 - Scienze biologiche > BIO/09 Fisiologia
Divisions:001 Università di Sassari > 03 Istituti > Clinica odontoiatrica
001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Academic Press / Elsevier
ISSN:0014-4886
Copyright Holders:© 2008 Elsevier
Deposited On:18 Aug 2009 10:04

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