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Is taurine beneficial in reducing risk factors for diabetes mellitus?

Franconi, Flavia and Di Leo, Mauro A. S. and Bennardini, Federico and Ghirlanda, Giovanni (2004) Is taurine beneficial in reducing risk factors for diabetes mellitus? Neurochemical Research, Vol. 29 (1), p. 143-150. eISSN 1573-6903. Article.

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DOI: 10.1023/B:NERE.0000010443.05899.2f

Abstract

Taurine is a semiessential amino acid, and its deficiency is involved in retinal and cardiac degenerations. In recent years, it was found that diabetes mellitus (DM) is associated with taurine, and many in vivo experimental studies showed that taurine administration is able to reduce the alterations induced by DM in the retina, lens, and peripheral nerve, although its effects on diabetic kidney are dubious. Interestingly, long-term taurine supplementation reduces the mortality rate in diabetic rats. The mechanisms by which taurine exerts beneficial effects in DM are discussed below. Recently, it has been suggested that taurine deficiency may alter the endocrine pancreas fetal programming, increasing the risk of insulin resistance in adult life. The bulk of experimental data suggests that taurine administration could be useful in the treatment of type 1 DM and in the prevention of insulin resistance.

Item Type:Article
ID Code:1209
Status:Published
Refereed:Yes
Uncontrolled Keywords:Taurine, diabetes mellitus, oxidative stress, insulin resistance
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Springer Netherlands
eISSN:1573-6903
Deposited On:18 Aug 2009 10:04

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