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Neonatal taurine administration modifies metabolic programming in male mice

Loizzo, Alberto and Carta, Stefania and Bennardini, Federico and Coinu, Rita and Loizzo, Stefano and Guarino, Irene and Seghieri, Giuseppe and Franconi, Flavia and Ghirlanda, Giovanni (2007) Neonatal taurine administration modifies metabolic programming in male mice. Early Human Development, Vol. 83 (10), p. 693-696. ISSN 0378-3782. Article.

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DOI: 10.1016/j.earlhumdev.2007.03.011

Abstract

The semi-essential amino-acid taurine is involved in glucose homeostasis either in adults or in parental life. Taurine is currently used in neonatal life because it is added to milk formula for babies, and to parental solution for prematures. Here, it has been examined whether taurine administration in lactation modifies adult glucose metabolism. Neonatally taurine-treated mice (50 mg/kg body weight/day, for the first 21 days of life) as adults have lower basal glucose and iAUC after glucose loading curves in comparison with vehicle-treated mice, whereas iAUC following insulin loading curves, plasma lipids and malondialdehyde (MDA), an index of lipid peroxidation were not significantly changed. Thus, in rodents, neonatally administered taurine produces enduring effects in a way that could be advantageous for the control of glucose homoeostasis.

Item Type:Article
ID Code:1204
Status:Published
Refereed:Yes
Uncontrolled Keywords:Taurine, neonatal administration, glycaemia, lipids, programming, mice
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Elsevier Ireland
ISSN:0378-3782
Additional Information:Pubblicato online il 9 maggio 2007.
Deposited On:18 Aug 2009 10:04

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