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Aspetti radiomici del tumore mammario: studio di associazione tra signature radiomica ed istotipo

Crivelli, Paola (2019) Aspetti radiomici del tumore mammario: studio di associazione tra signature radiomica ed istotipo. Doctoral Thesis.

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Abstract

Aim of this study is to assess the role of radiomics in breast cancer, focusing on its ability to predict histological phenotypes.
Methods: It was carried out a retrospective study including all breast cancer patients who referred to the Diagnostic Imaging 2 Institute to perform a breast MRI prior to surgery. Histologic confirmation on surgical specimen was obtained in all patients.
Results: All patients underwent a high-field (1,5 T) breast MRI (T2-weight sequences with fat suppression, T1-weight sequences and T1 after IV contrast administration). MRI enhanced sequences were contoured and first-order radiomics features were extracted through dedicated software, called 3DSlicer. Taking into account the current literature, three features were selected: entropy, 90° percentile and skewness. The association between the selected features and the histological patterns were explored.
Conclusion: A possible integration of quantitative data, provided by a radiomics analysis, with clinical and histological data could enable clinicians to provide an early and accurate diagnosis as well as personalized treatments for breast cancer patients. Current limitations of a routinely application of radiomics seem both the limited knowledge among physicians of this quantitative radiological tool and the lack of standardized systems of feature extraction and data sharing.

Item Type:Doctoral Thesis
ID Code:12011
Contributors:Capobianco, Giampiero
Publisher:Universita' degli studi di Sassari
Uncontrolled Keywords:Radiomica, RM, tumore mammario, prognosi, istotipo
Subjects:Area 06 - Scienze mediche > MED/36 Diagnostica per immagini e radioterapia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Cicli, scuole e corsi:Ciclo 32 > Scienze biomediche > Medicina di genere, dell'uomo, della donna e del bambino
Deposited On:05 Jun 2019 10:12

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