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Studio di alcuni oli essenziali nella pratica clinica

Donadu, Matthew Gavino (2018) Studio di alcuni oli essenziali nella pratica clinica. Doctoral Thesis.

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Abstract

During the Ph.D. period, mastery of several traditional microbiology techniques, such as bacteriology and cytology, and molecular techniques was acquired, with application on randomized clinical trials.
The research activity has focused mainly on in vitro antibacterial, antioxidant and cytotoxic activity with subsequent application of some essential oils in vivo on animals and on humans.
Considering the results obtained, it is clear that Thymus vulgaris - red thyme geraniol sel and L. grosso oils have shown good antimicrobial activity, compared to L. angustifolia and L. sumian on multi-drug clinical strains of P. aeruginosa. While L. angustifolia Miller presented a cytotoxic action on CaCo-2 cells (Colon-carcinoma Carcinoma Cells) probably due to the action of terpenes.
The oleolites of Helichrysum microphyllum Cambess. subsp. tyrrhenicum Bacch., Brullo & Giusso and Hypericum perforatum subsp. Angustifolium were tested against 30 strains of Candida spp.: the oleolite of H. microphyllum showed greater antifungal activity compared to H. perforatum.
Finally, the antifungal action of Mirtus communis was studied against 86 strains of Malassezia spp.: the obtained data showed a remarkable activity against M. furfur and M. sympodialis.
Furthermore, an in vivo study was performed and we present here the preliminary data.
The topic developed is part of a research area aimed at the use of essential oils with antibacterial activity in the problem of drug resistance.

Item Type:Doctoral Thesis
ID Code:11967
Contributors:Zanetti, Stefania Anna Lucia and Usai, Donatella
Publisher:Universita' degli studi di Sassari
Uncontrolled Keywords:Oli essenziali, pratica clinica, antibiotico resistenza, in vivo, medicina naturale
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Cicli, scuole e corsi:Ciclo 31 > Life sciences and biotechnologies
Deposited On:19 Apr 2019 12:50

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