Paliogiannis, Panagiotis and Fois, Alessandro Giuseppe and Sotgia, Salvatore and Mangoni, Arduino A. and Zinellu, Elisabetta and Pirina, Pietro and Negri, Silvia and Carru, Ciriaco and Zinellu, Angelo (2018) Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives. European Respiratory Review, Vol. 27 (170113). ISSN 0905-9180. eISSN 1600-0617. Article.
Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterised by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD are a common cause of hospitalisation and death among COPD patients. Several biochemical markers have been studied as outcome predictors in COPD; however, their measurement often requires significant time and resources. Relatively simple biomarkers of inflammation calculated from routine complete blood count tests, such as the neutrophil to lymphocyte ratio (NLR), might also predict COPD progression and outcomes. This review discusses the available evidence from studies investigating the associations between the NLR, COPD exacerbations and death in this patient group.
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