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Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives

Paliogiannis, Panagiotis and Fois, Alessandro Giuseppe and Sotgia, Salvatore and Mangoni, Arduino A. and Zinellu, Elisabetta and Pirina, Pietro and Negri, Silvia and Carru, Ciriaco and Zinellu, Angelo (2018) Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives. European Respiratory Review, Vol. 27 (170113). ISSN 0905-9180. eISSN 1600-0617. Article.

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DOI: 10.1183/16000617.0113-2017

Abstract

Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterised by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD are a common cause of hospitalisation and death among COPD patients. Several biochemical markers have been studied as outcome predictors in COPD; however, their measurement often requires significant time and resources. Relatively simple biomarkers of inflammation calculated from routine complete blood count tests, such as the neutrophil to lymphocyte ratio (NLR), might also predict COPD progression and outcomes. This review discusses the available evidence from studies investigating the associations between the NLR, COPD exacerbations and death in this patient group.

Item Type:Article
ID Code:11935
Status:Published
Refereed:Yes
Uncontrolled Keywords:Chronic obstructive pulmonary disease (COPD), neutrophil to lymphocyte ratio (NLR), clinical outcomes
Subjects:Area 06 - Scienze mediche > MED/10 Malattie dell'apparato respiratorio
Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > AOU -Azienda Ospedaliero Universitaria, Sassari
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:European Respiratory Society
ISSN:0905-9180
eISSN:1600-0617
Publisher Policy:The European Respiratory Review is free to access online and there are no article processing charges. All ERR papers are free to read, share and reuse for non-commercial purposes under the CC-BY-NC 4.0 licence
Deposited On:05 Mar 2018 11:01

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