titoli, abstracts, parole chiave >>>
Peripheral neuromodulation for drug-resistant epilepsy: the effect of short term transcutaneous trigeminal nerve stimulation on EEG activity

Fois, Chiara (2018) Peripheral neuromodulation for drug-resistant epilepsy: the effect of short term transcutaneous trigeminal nerve stimulation on EEG activity. Doctoral Thesis.

[img]Full text disponibile come PDF Richiede visualizzatore di PDF come GSview, Xpdf o Adobe Acrobat Reader
Restricted to until 12 July 2019.



Aim: Trigeminal nerve stimulation (TNS) has been proven to exert beneficial effects on symptoms of drug-resistant epilepsy (DRE). However, whether and how TNS is able to modulate the electroencephalogram (EEG) background activity in DRE patients is still unknown. We aimed to investigate the effect of acute TNS on EEG activity by conducting qualitative (morphologic) and quantitative (power spectra) analyses on two groups of DRE patients, undergoing real or sham TNS.

Methods: Twenty-two DRE patients were randomly divided into a “sham-TNS” or “real-TNS” group. Real-TNS was delivered bilaterally to the infraorbital nerve with trains of a symmetric biphasic square wave pulse (1 to 20 mA, 120 Hz), in a cyclic modality for 20 minutes. The sham-TNS protocol mimicked the real-TNS stimulation but at a zero intensity. EEG recordings were collected for each patient 10 minutes pre, 20 minutes during and 10 minutes post TNS delivery. EEG signal was subsequently visually analysed for interictal epileptiform discharge (IEDs) and processed by spectral analysis (Fast Fourier Transform). A between and within subject repeated-measures ANOVA was used for statistical analyses.

Results: A significant increase of EEG absolute alpha power was observed in the during real-TNS compared to the sham-TNS (F2,18=1.748; p=0.006). Conversely, no significant effects were noticed either for quantitative analysis of other frequency bands or for IEDs detection.

Conclusion: Short-term TNS is able to induce an acute effect on EEG background composition of DRE patients. In line with recent evidence, alpha rhythm enhancement might be interpreted as an index of functional inhibition, able to influence cortical activity and thus reduce seizure propensity.

Item Type:Doctoral Thesis
ID Code:11864
Contributors:Sechi, Gianpietro and Deriu, Franca
Publisher:Universita' degli studi di Sassari
Uncontrolled Keywords:Epilessia farmaco-resistente, stimolazione nervosa trigeminale, neuromodulazione, EEG quantitativo
Subjects:Area 05 - Scienze biologiche > BIO/09 Fisiologia
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Cicli, scuole e corsi:Ciclo 30 > Scienze biomediche > Neuroscienze
Deposited On:07 Jun 2018 15:40

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page