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Studio della virulenza di Staphylococcus spp isolati da protesi mammarie

Ganau, Giulia (2018) Studio della virulenza di Staphylococcus spp isolati da protesi mammarie. Doctoral Thesis.

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Abstract

In recent years the use of breast surgery, has undergone an exponential increase, both for aesthetic and reconstructive purposes. The main complication as a result of these interventions is due to the bacterial colonization of the breast implants resulting in infection of the affected site. As a result of the diagnosis of an infection, the only possible therapy involves the removal of the implant followed by antibiotic treatment. The main culprits of such infections are Staphylococcus spp. It was possible to study the pathogenicity of these strains from a genetic point of view by identifying specific virulence genes such as icaA, bhp, kdp, agrD, IS256 and IS257. Moreover, it has been studied their adhesive capacity both on epithelioid Caco2 cells and on all types of prosthetic surfaces, comparing with ATCC control samples. Their ability to produce biofilms was compared with ATCC strains, clinical control samples and skin-isolated specimens of healthy voluntary women has also been studied. The study has made it possible to broaden the knowledge of these particular infections hitherto poorly studied and to lay the basis for future interventions of prevention and advancement in the diagnostic and surgical methods.

Item Type:Doctoral Thesis
ID Code:11853
Contributors:Rubino, Salvatore
Publisher:Universita' degli studi di Sassari
Uncontrolled Keywords:Staphylococcus, protesi mammarie, PJI
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Cicli, scuole e corsi:Ciclo 30 > Scienze biomediche
Deposited On:08 Jun 2018 09:34

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