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Combining HLA-DRB1-DQB1 and Mycobacterium avium subspecies paratubercolosis (MAP) antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors?

Frau, Jessica and Cossu, Davide and Sardu, Claudia and Mameli, Giuseppe and Coghe, Giancarlo and Lorefice, Lorena and Fenu, Giuseppe and Tranquilli, Stefania and Sechi, Leonardo Antonio and Marrosu, Maria Giovanna and Cocco, Eleonora (2016) Combining HLA-DRB1-DQB1 and Mycobacterium avium subspecies paratubercolosis (MAP) antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors? BMC Neurology, Vol. 16 (148), p. 4. ISSN 1471-2377. Article.

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DOI: 10.1186/s12883-016-0669-1

Abstract

Background: Amongst Sardinians the human leukocyte antigen (HLA) DRB1-DQB1 haplotypes *15:02-*06:01, *16:01-*05:02, *14:01-4-*05:03 are protective for multiple sclerosis (MS), while *13:03-*03:01, *04:05-*03:01, *03:01-*02:01, *15:01-*06:02 and Mycobacterium avium subspecies paratubercolosis (MAP) are predisposing factors. We studied the correlation between MAP and HLA.
Methods: Five hundred thirty-one patients were searched for anti-MAP2694 antibodies, DRB1-DQB1 genotyping was performed. The haplotypes were classified as predisposing, neutral or protective.
Results: Anti-MAP2694 were found in 23 % of subjects carrying one protective HLA versus 32 % without (p = 0.04).
Conclusions: We showed a lower frequency of Abs in patients with protective HLA. These haplotypes could have a protective role for both MS and MAP.

Item Type:Article
ID Code:11791
Status:Published
Refereed:Yes
Uncontrolled Keywords:Mycobacterium avium subspecies paratuberculosis, multiple sclerosis, HLA, Sardinia
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:PubMed Central
ISSN:1471-2377
Copyright Holders:©  The Author(s). 2016
Deposited On:20 Sep 2017 12:08

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