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On the accuracy of in vivo ethanol and acetaldehyde monitoring, a key tile in the puzzle of acetaldehyde as a neuroactive agent

Enrico, Paolo and Diana, Marco (2017) On the accuracy of in vivo ethanol and acetaldehyde monitoring, a key tile in the puzzle of acetaldehyde as a neuroactive agent. Frontiers in behavioral neuroscience, Vol. 11 (97), p. 7. eISSN 1662-5153. Article.

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DOI: 10.3389/fnbeh.2017.00097

Abstract

Over the last 20 years researchers have explored the postulated role of acetaldehyde (ACD) as a mediator of some of the actions of ethanol (EtOH) in the central nervous system (CNS). However, efforts have been hampered mainly by the difficulty of directly measuring in vivo EtOH and ACD levels in the CNS and thus, our knowledge is based on indirect evidences. Although technically challenging, the development of reliable methods for in vivo measurement of ACD and EtOH is of paramount importance to solve the “puzzle of acetaldehyde as a neuroactive agent.” In this short review we discuss the recent advances on brain EtOH pharmacokinetic and state-of-the-art available techniques that could be used for in vivo detect EtOH and ACD both non-invasively (magnetic resonance spectroscopy), and invasively (microdialysis and biosensors). Among the different in vivo sampling techniques described, particular emphasis is paid to the field of enzyme-based amperometric biosensors. Biosensors have gained much attention in recent years for their ability to online monitor biological signals in vivo, and several micro- and nano-structured devices have been successfully used for in vivo studies. Owing to their high temporal and spatial resolution, biosensors could provide the adequate technology for studying in vivo EtOH pharmacokinetic.

Item Type:Article
ID Code:11777
Status:Published
Refereed:Yes
Uncontrolled Keywords:Ethanol, acetaldehyde, magnetic resonance spectroscopy, microdialysis, biosensors
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Frontiers Research Foundation
eISSN:1662-5153
Copyright Holders:© 2017 Enrico and Diana
Deposited On:20 Jun 2017 09:17

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