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Plasma clusterin and lipid profile: a link with aging and cardiovascular diseases in a population with a consistent number of centenarians

Baralla, Angela and Sotgiu, Elisabetta and Deiana, Marta and Pasella, Sara and Pinna, Sara and Mannu, Andrea and Canu, Elisabetta and Sotgiu, Giovanni and Ganau, Antonello and Zinellu, Angelo and Sotgia, Salvatore and Carru, Ciriaco and Deiana, Luca (2015) Plasma clusterin and lipid profile: a link with aging and cardiovascular diseases in a population with a consistent number of centenarians. PLoS One, Vol. 10 (6), e0128029. ISSN 1932-6203. Article.

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DOI: 10.1371/journal.pone.0128029

Abstract

The role of Clusterin in attenuation of inflammation and reverse cholesterol transfer makes this molecule a potential candidate as a marker for cancer, cardiovascular disease, diabetes mellitus, and metabolic syndrome. In elderly subjects cardiovascular diseases represent the primary cause of death and different clinical studies have shown a positive correlation of these diseases with changes in the lipid pattern. This work aimed at evaluating the relationship between circulating clusterin and the biochemical parameters that characterize the lipid profile of a Sardinian population divided into five age groups including centenarians; the high frequency in Sardinia of these long-lived individuals gave us the opportunity to extend the range of the age groups to be analyzed to older ages and to better evaluate the changes in the lipid balance during ageing and its relationship with clusterin concentration in plasma. Our results showed that Clusterin concentration values of the youngest group were more similar with the centenarian’s group compared to the other age groups, and a positive correlation arises with LDL. Furthermore given the high prevalence of cardiovascular diseases in the population examined and the association of Clusterin with these pathologies we evaluated Clusterin concentration variation in two groups with or without cardiovascular diseases. In presence of cardiovascular disease, Clusterin is significantly related to the most atherogenic components of lipid profile (total cholesterol and LDL), especially in women, suggesting its potential role in modulating cardiovascular metabolic risk factors.

Item Type:Article
ID Code:11772
Status:Published
Refereed:Yes
Uncontrolled Keywords:Cholesterol, cardiovascular diseases, age groups, lipoproteins, lipids, aging, elderly, blood plasma
Subjects:Area 06 - Scienze mediche > MED/11 Malattie dell'apparato cardiovascolare
Area 06 - Scienze mediche > MED/10 Malattie dell'apparato respiratorio
Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Public Library of Science
ISSN:1932-6203
Copyright Holders:© 2015 Baralla et al.
Deposited On:15 Jun 2017 09:18

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