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A Speciation study on the perturbing effects of iron chelators on the homeostasis of essential metal ions

Crisponi, Guido and Nurchi, Valeria Marina and Crespo-Alonso, Miriam and Sanna, Gavino and Zoroddu, Maria Antonietta and Alberti, Giancarla and Biesuz, Raffaela (2015) A Speciation study on the perturbing effects of iron chelators on the homeostasis of essential metal ions. PLoS One, Vol. 10 (7), e0133050. ISSN 1932-6203. Article.

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DOI: 10.1371/journal.pone.0133050


A number of reports have appeared in literature calling attention to the depletion of essential metal ions during chelation therapy on β-thalassaemia patients. We present a speciation study to determine how the iron chelators used in therapy interfere with the homeostatic equilibria of essential metal ions. This work includes a thorough analysis of the pharmacokinetic properties of the chelating agents currently in clinical use, of the amounts of iron, copper and zinc available in plasma for chelation, and of all the implied complex formation constants. The results of the study show that a significant amount of essential metal ions is complexed whenever the chelating agent concentration exceeds the amount necessary to coordinate all disposable iron —a frequently occurring situation during chelation therapy. On the contrary, copper and zinc do not interfere with iron chelation, except for a possible influence of copper on iron speciation during deferiprone treatment.

Item Type:Article
ID Code:11768
Uncontrolled Keywords:Zinc, iron, chelation, blood plasma, albumins, pharmacokinetics, drug administration, copper
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Area 03 - Scienze chimiche > CHIM/10 Chimica degli alimenti
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Public Library of Science
Copyright Holders:© 2015 Crisponi et al.
Deposited On:14 Jun 2017 17:12

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