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Y chromosome binary markers to study the high prevalence of males in Sardinian centenarians and the genetic structure of the Sardinian population

Passarino, Giuseppe and Underhill, Peter A. and Cavalli-Sforza, Luca and Baggio, Giovannella and Semino, Ornella and Pes, Giovanni Mario and Carru, Ciriaco and Ferrucci, Luigi and Bonafè, Massimiliano and Franceschi, Claudio and Deiana, Luca and De Benedictis, Giovanna (2001) Y chromosome binary markers to study the high prevalence of males in Sardinian centenarians and the genetic structure of the Sardinian population. Human Heredity, Vol. 52 (3), p. 136-139. ISSN 0001-5652. Article.

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DOI: 10.1159/000053368

Abstract

We have analyzed a sample of 40 centenarians and 116 young controls from Sardinia, with a set of new Y chromosome binary markers, to evaluate if Y chromosome genes are involved in the high prevalence of males among centenarian Sardinians (1/2 vs. 1/4 in other populations studied). The results indicate that none of the seven lineages that account for >97% of the Y chromosome diversity in Sardinia provide an advantage with respect to the extreme longevity. However, our results, although based on the male-specific Y chromosome polymorphisms, give a clear profile of the pattern of genetic variability in Sardinia. Indeed they indicate that the Sardinian population had two main founder populations that have evolved in isolation for at least the last 5,000 years. These findings set the stage for future studies on longevity and other complex traits in Sardinia.

Item Type:Article
ID Code:1176
Status:Published
Refereed:Yes
Uncontrolled Keywords:Y chromosome, centenarians, longevity, Sardinia, isolated population
Subjects:Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Area 06 - Scienze mediche > MED/09 Medicina interna
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Karger
ISSN:0001-5652
Deposited On:18 Aug 2009 10:04

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