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Carboplatin sustained delivery system using injectable microspheres

Manunta, Maria Lucia Gabriella M. and Gavini, Elisabetta and Chessa, Giannina and Sanna Passino, Eraldo and Careddu, Giovanni Mario and Giua, S. and Mollica, Alessandra and Demontis, Maria Piera and Leoni, Antonio and Muzzetto, Paolo (2005) Carboplatin sustained delivery system using injectable microspheres. Journal of Veterinary Medicine Series A, Vol. 52 (8), p. 416-422. ISSN 0931-184X. Article.

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DOI: 10.1111/j.1439-0442.2005.00751.x

Abstract

A controlled carboplatin delivery system using biodegradable polymer has been used in this study. The purpose was to evaluate the local and systemic effects of injectable, biodegradable microspheres containing carboplatin when injected as aqueous suspension subcutaneously in rats. Biocompatibility and toxicity of empty microspheres and microspheres loaded with carboplatin were evaluated by clinical and histological examination. The diffusion of carboplatin in tissues and time of drug release were evaluated by platinum determination in plasma and tissues over the time. The results of the study suggest that microspheres provide a sustained slow release of carboplatin and that multiple inoculations of microspheres containing drug and no evidence of local or systemic toxicity is found. This device may be useful in the treatment of solid tumours.

Item Type:Article
ID Code:1173
Status:Published
Refereed:Yes
Uncontrolled Keywords:Carboplatin, injectable microspheres
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/09 Clinica chirurgica veterinaria
Area 03 - Scienze chimiche > CHIM/09 Farmaceutico tecnologico applicativo
Area 07 - Scienze agrarie e veterinarie > VET/03 Patologia generale e anatomia patologica veterinaria
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Istituto zooprofilattico sperimentale della Sardegna, Sassari
001 Università di Sassari > 01 Dipartimenti > Patologia e clinica veterinaria
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Blackwell / Wiley
ISSN:0931-184X
Deposited On:18 Aug 2009 10:04

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