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Endogenous jaagsiekte sheep retrovirus RNA is expressed by different cell types in ovine foetus and placenta

Sanna, Ennio and Sanna, Maria Paola and Loddo, C. and Sanna, Luciano Angelo Salvatore and Mura, M. and Cadelano, T. and Leoni, Antonio (2002) Endogenous jaagsiekte sheep retrovirus RNA is expressed by different cell types in ovine foetus and placenta. European Journal of Histochemistry, Vol. 46 (3), p. 273-280. ISSN 1121-760X. Article.

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The endogenous retroviruses are inherited elements transmitted trough the germline of most animal species and their biological role is still controversial. Ovine Pulmonary Carcinoma (OPC) represents a good model for studying the interactions of endogenous retroviruses with their exogenous counterparts. The type D exogenous retrovirus known as Jaagsiekte Sheep Retro-Virus (JSRV) is necessary and sufficient to cause OPC in domestic and wild sheep, but both affected and unaffected animals host in their genome 15 to 20 copies of related endogenous retroviruses named endogenous JSRV (enJSRV). In this study we evaluated the expression of enJSRV gag sequences in ovine foetal and placental tissues. RNA in situ hybridisation was performed on tissue sections of thymi, lymph nodes and lungs from ovine foetuses and related placentas, taken at a late stage of development. Reverse transcriptase-in situ polymerase chain reactions were also carried out on placental samples to better define the involved cells. In foetal tissues, specific signals were observed in the thymus medulla, lymph nodes and, at a lesser extent, in foetal bronchiolar cells. In the placental tissues, positive areas were detected in various cell types in the sincythium-and cyto-trophoblast. These data demonstrate that en JSRV RNA is largely expressed in a broad spectrum of cells including tissues which are critical for the development of the immune system.

Item Type:Article
ID Code:1172
Uncontrolled Keywords:enJRSV, RNA, sheep, foetus, placenta
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/03 Patologia generale e anatomia patologica veterinaria
Divisions:001 Università di Sassari > 01 Dipartimenti > Patologia e clinica veterinaria
Publisher:Luigi Ponzio
Copyright Holders:© Luigi Ponzio e figlio - Editori in Pavia, © 2009 PagePress
Deposited On:18 Aug 2009 10:04

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