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G6PD deficiency does not enhance susceptibility for acquiring Helicobacter pylori infection in Sardinian patients

Dore, Maria Pina and Marras, Giuseppina and Rocchi, Chiara and Soro, Sara and Pes, Giovanni Mario (2016) G6PD deficiency does not enhance susceptibility for acquiring Helicobacter pylori infection in Sardinian patients. PLoS One, Vol. 11 (7), e0160032. ISSN 1932-6203. Article.

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DOI: 10.1371/journal.pone.0160032

Abstract

Background: Subjects with glucose-6-phosphate dehydrogenase (G6PD) deficiency may be more susceptible to infections due to impaired leukocyte bactericidal activity. The disorder is common in the Mediterranean area. The aim of this study was to investigate whether G6PD deficiency may be a risk factor for acquiring H. pylori infection.
Methods: We performed a retrospective study. Data from clinical records of 6565 patients (2278 men and 4287 women, median age 51, range 7‒94) who underwent upper endoscopy between 2002 and 2014 were collected. H. pylori status, assessed by histology plus rapid urease test or 13C-urea breath test, and G6PD status were also reported. A multiple logistic regression model was used to investigate the association between G6PD deficiency and H. pylori infection.
Results: Enzyme deficiency was detected in 12% (789/6565) of the entire cohort, and more specifically in 8.3% of men and in 14.0% of women. Overall, the proportion of patients positive for H. pylori was 50.6% and 51.5% among G6PD deficient and non-deficient patients (χ² = 0.271; p = 0.315). Moreover, among G6PD-deficient and normal patients the frequency of previous H. pylori infection was similar. After adjustment for age and gender the risk for acquiring H. pylori infection was similar in G6PD-deficient and normal patients. Only age was a strong statistically significant risk predictor.
Conclusions: These results demonstrate for the first time that G6PD deficiency does not enhance patients’ susceptibility to acquire H. pylori infection in Sardinia.

Item Type:Article
ID Code:11711
Status:Published
Refereed:Yes
Uncontrolled Keywords:Helicobacter pylori, glucose-6-phosphate dehydrogenase deficiency, gastrointestinal infections, gastritis, atrophy, Helicobacter pylori infection, biopsy, red blood cells, Sardinia
Subjects:Area 06 - Scienze mediche > MED/12 Gastroenterologia
Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Public Library of Science
ISSN:1932-6203
Copyright Holders:© 2016 Dore et al.
Deposited On:17 May 2017 16:20

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