Sanna, Maria Paola and Sanna, Ennio and De Las Heras, M. and Leoni, Antonio and Nieddu, Antonio Mario S. and Pirino, Salvatore and Sharp, J. M. and Palmarini, Massimo (2001) Association of Jaagsiekte Sheep Retrovirus with pulmonary carcinoma in Sardinian moufflon (Ovis musimon). Journal of Comparative Pathology, Vol. 125 (2-3), p. 145-152. ISSN 0021-9975. Article.
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Bronchiolo-alveolar carcinoma has been described in man and in several animal species, including cattle, dogs, opossums, goats and sheep. In sheep, a bronchiolo-alveolar carcinoma, known as ovine pulmonary carcinoma (OPC), is caused by jaagsiekte sheep retrovirus (JSRV), an exogenous type D retrovirus. In the mid-1980s, a severe outbreak of a disease resembling OPC was described in captive Sardinian moufflon (Ovis musimon). In the present study, the use of polymerase chain reaction (PCR) amplification of nucleic acids extracted from archival material established that JSRV was associated with OPC in affected moufflon. JSRV was detected in the lungs and mediastinal lymph nodes. Immunohistochemical and in-situ PCR demonstrated that in the lungs, JSRV proviral DNA was localized in transformed and untransformed type II pneumocytes and in the alveolar macrophages. In the mediastinal lymph nodes, JSRV DNA was mainly located in the cortical follicles and paracortex. These data suggest that JSRV is the cause of OPC in Sardinian moufflon, as it is in Sardinian sheep.
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