Bonafè, Massimiliano and Olivieri, Fabiola and Mari, Daniela and Baggio, Giovannella and Mattace, Rosario and Berardelli, Maurizio and Sansoni, Paolo and De Benedictis, Giovanna and De Luca, Maria and Marchegiani, Francesca and Cavallone, Luca and Cardelli, Maurizio and Giovagnetti, Simona and Ferrucci, Luigi and Amadio, Loredana and Lisa, Rosamaria and Tucci, Maria Giovanna and Troiano, Leonarda and Pini, Gabriella and Gueresi, Paola and Morellini, Marina and Sorbi, Sandro and Passeri, Giovanni and Barbi, Cristiana and Valensin, Silvana and Monti, Daniela and Deiana, Luca and Pes, Giovanni Mario and Carru, Ciriaco and Franceschi, Claudio (1999) P53 Codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia. The American Journal of Human Genetics, Vol. 65 (6), p. 1782-1785. ISSN 0002-9297. Article.
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In a previous letter (Bonafè et al. 1999) we tested the hypothesis that polymorphic variants of p53 have an impact on human longevity, by comparing p53 codon 72 allelic and genotypic frequency distributions between young people and centenarians. A nonsignificant difference emerged between the groups, and several explanations were offered. Following the reply letter of Sun et al. (in this issue), we would like to argue with some of their comments and to provide new data regarding centenarians from continental Italy and Sardinia.
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