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P53 Codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia

Bonafè, Massimiliano and Olivieri, Fabiola and Mari, Daniela and Baggio, Giovannella and Mattace, Rosario and Berardelli, Maurizio and Sansoni, Paolo and De Benedictis, Giovanna and De Luca, Maria and Marchegiani, Francesca and Cavallone, Luca and Cardelli, Maurizio and Giovagnetti, Simona and Ferrucci, Luigi and Amadio, Loredana and Lisa, Rosamaria and Tucci, Maria Giovanna and Troiano, Leonarda and Pini, Gabriella and Gueresi, Paola and Morellini, Marina and Sorbi, Sandro and Passeri, Giovanni and Barbi, Cristiana and Valensin, Silvana and Monti, Daniela and Deiana, Luca and Pes, Giovanni Mario and Carru, Ciriaco and Franceschi, Claudio (1999) P53 Codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia. The American Journal of Human Genetics, Vol. 65 (6), p. 1782-1785. ISSN 0002-9297. Article.

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DOI: 10.1086/302664

Abstract

In a previous letter (Bonafè et al. 1999) we tested the hypothesis that polymorphic variants of p53 have an impact on human longevity, by comparing p53 codon 72 allelic and genotypic frequency distributions between young people and centenarians. A nonsignificant difference emerged between the groups, and several explanations were offered. Following the reply letter of Sun et al. (in this issue), we would like to argue with some of their comments and to provide new data regarding centenarians from continental Italy and Sardinia.

Item Type:Article
ID Code:1168
Status:Published
Refereed:Yes
Uncontrolled Keywords:Centenarians, longevity, P53, cancer and aging, cancer risk factors
Subjects:Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Area 06 - Scienze mediche > MED/09 Medicina interna
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Cell Press / Elsevier
ISSN:0002-9297
Copyright Holders:© 1999 The American Society of Human Genetics
Deposited On:18 Aug 2009 10:04

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