Caggiu, Sabrina (2017) La Tecnologia REAC in medicina veterinaria: esperienze sperimentali e cliniche. Doctoral Thesis.
Radio Electric Asymmetric Conveyer (REAC) Technology is a platform technology for bio and neuro modulation, patented at international level (WO2001EP07800, EP1301241, US7333859 and other patents pending). The scientific background of REAC technology platform is based on a fundamental phenomenon for life: cells have an asymmetric structure, as several cellular components, including plasma membrane, cytoskeleton or organelles, asymmetrically organized. This cell structure implies that ion channels are asymmetrically distributed throughout cellular membrane and this generates ionic fluxes. These ionic fluxes in turn produce currents and these currents produce bioelectric fields. This phenomenon takes the name of "Cell polarity". Cell polarity is at the base of correct cell bioelectric activity and is implicated in important processes that influence normal cell functions such as cell differentiation, proliferation, morphogenesis, migration and neurotransmission in unicellular and multicellular organisms. Epigenetic factors, trauma, infections and other factors alter the mechanism of action of the cell polarity. This blocks the correct production of ion fluxes in cells and tissues, and consequently it alters electro-metabolic activity, functions and reparative processes in cells and tissues. The mechanism of action of REAC Technology is aimed to restore the correct cell polarity. This optimization of cell polarity allows the proper recovery of cellular electro-metabolic processes, moreover cell migration, proliferation and differentiation, by promoting reparative and regenerative process of tissues. REAC technology is so effective to induce remarkable biological effects at many scales, from gene modulations up to functional neuro biological optimization. The effects of REAC Technology are completely pervasive and have no limit in depth in the tissues to be treated. The results obtained in vitro and in vivo suggestarole of REAC in regenerative medicine that opens new scenarios in neurological, vascular, orthopaedic, trauma, and tissue repair. The key features of REAC technology are the absolute safety, ease of use, the presence of effective standardized protocols validated by years of use and the ability to be associated with other pharmacological and surgical treatments, supporting and enhancing them. All these features can open up new perspectives of REAC technology use in veterinary medicine.
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