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Inhibition of an erythrocyte tyrosine kinase with imatinib prevents Plasmodium falciparum egress and terminates parasitemia

Kesely, Kristina R. and Pantaleo, Antonella and Turrini, Francesco Michelangelo and Olupot-Olupot, Peter and Low, Philip S. (2016) Inhibition of an erythrocyte tyrosine kinase with imatinib prevents Plasmodium falciparum egress and terminates parasitemia. PLoS One, Vol. 11 (10), e0164895. ISSN 1932-6203. Article.

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DOI: 10.1371/journal.pone.0164895

Abstract

With half of the world’s population at risk for malaria infection and with drug resistance on the rise, the search for mutation-resistant therapies has intensified. We report here a therapy for Plasmodium falciparum malaria that acts by inhibiting the phosphorylation of erythrocyte membrane band 3 by an erythrocyte tyrosine kinase. Because tyrosine phosphorylation of band 3 causes a destabilization of the erythrocyte membrane required for parasite egress, inhibition of the erythrocyte tyrosine kinase leads to parasite entrapment and termination of the infection. Moreover, because one of the kinase inhibitors to demonstrate antimalarial activity is imatinib, i.e. an FDA-approved drug authorized for use in children, translation of the therapy into the clinic will be facilitated. At a time when drug resistant strains of P. falciparum are emerging, a strategy that targets a host enzyme that cannot be mutated by the parasite should constitute a therapeutic mechanism that will retard evolution of resistance.

Item Type:Article
ID Code:11575
Status:Published
Refereed:Yes
Uncontrolled Keywords:Parasitic diseases, parasitic life cycles, parasitemia, malarial parasites, Plasmodium, red blood cells, malaria, tyrosine kinases
Subjects:Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Public Library of Science
ISSN:1932-6203
Copyright Holders: © 2016 Kesely et al.
Deposited On:11 Apr 2017 11:08

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