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Nanoencapsulation of dietary flavonoid fisetin: formulation and in vitro antioxidant and α-glucosidase inhibition activities

Sechi, Mario and Syed, Deeba Nadeem and Pala, Nicolino and Mariani, Alberto and Marceddu, Salvatore and Brunetti, Antonio and Mukhtar, Hasan and Sanna, Vanna Annunziata (2016) Nanoencapsulation of dietary flavonoid fisetin: formulation and in vitro antioxidant and α-glucosidase inhibition activities. Materials Science and Engineering C, Vol. 68 , p. 594-602. ISSN 0928-4931. Article.

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DOI: 10.1016/j.msec.2016.06.042

Abstract

The bioactive flavonoid fisetin (FS) is a diet-derived antioxidant that is being increasingly investigated for its health-promoting effects. Unfortunately, the poor physicochemical and pharmacokinetic properties affect and limit the clinical application.
In this study, novel polymeric nanoparticles (NPs), based on Poly-(ε-caprolactone) (PCL) and PLGA-PEG-COOH, encapsulating FS were formulated as suitable oral controlled release systems. Results showed NPs having a mean diameter of 140–200 nm, and a percent loading of FS ranging from 70 to 82%. In vitro release studies revealed that NPs are able to protect and preserve the release of FS in gastric simulated conditions, also controlling the release in the intestinal medium. Moreover, the DPPH and ABTS scavenging capacity of FS, as well as α-glucosidase inhibition activity, that resulted about 20-fold higher than commercial Acarbose, were retained during nanoencapsulation process.
In summary, our developed NPs can be proposed as an attractive delivery system to control the release of antioxidant and anti-hyperglycemic FS for nutraceutical and/or therapeutic application.

Item Type:Article
ID Code:11478
Status:Published
Refereed:Yes
Uncontrolled Keywords:Fisetin, nanoparticles, controlled release, antioxidant activity, α-glucosidase inhibition
Subjects:Area 02 - Scienze fisiche > FIS/07 Fisica applicata (a beni culturali, ambientali, biologia e medicina)
Area 03 - Scienze chimiche > CHIM/04 Chimica industriale
Area 03 - Scienze chimiche > CHIM/10 Chimica degli alimenti
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Politiche, Scienze della Comunicazione e Ingegneria dell'Informazione
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di scienze delle produzioni alimentari, Sassari
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Elsevier
ISSN:0928-4931
Deposited On:20 Oct 2016 08:58

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