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Natalizumab modulates the humoral response against HERV-Wenv73–88 in a follow-up study of Multiple Sclerosis patients

Arru, Giannina and Caggiu, Elisa and Leoni, Stefania and Mameli, Giuseppe and Pugliatti, Maura and Sechi, Gianpietro and Sechi, Leonardo Antonio (2015) Natalizumab modulates the humoral response against HERV-Wenv73–88 in a follow-up study of Multiple Sclerosis patients. Journal of the Neurological Sciences, Vol. 357 (1-2), p. 106-108. ISSN 0022-510X. Article.

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DOI: 10.1016/j.jns.2015.07.007

Abstract

Multiple Sclerosis (MS) is a heterogeneous disorder of the central nervous system (CNS) that begins as an inflammatory autoimmune disorder mediated by auto-reactive lymphocyte followed by microglial activation and chronic degeneration. The etiology of Multiple Sclerosis (MS) is unknown but several data support the hypothesis of possible infectious agents which may act as a trigger for the pathogenic cascade. Human endogenous retrovirus (HERV-W/MSRV), Epstein Barr Virus (EBV) and Mycobacterium avium ss. paratuberculosis (MAP) have been associated to Multiple Sclerosis. In this study, we evaluated the humoral response against different peptides: the human endogenous retrovirus HERV-Wenv73–88, MAP106c121–132 from MAP, EBNA1 400–413 from EBV and the homologous human peptide MBP85–98 in a cohort of MS patients treated with natalizumab. Results showed a statistically significant difference in the response against the HERV-W peptide in MS patients after two years of natalizumab treatment.

Item Type:Article
ID Code:11330
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multiple Sclerosis, Natalizumab therapy, HERV-Wenv, Epstein Barr Virus (EBV), Mycobacterium avium ss. paratuberculosis (MAP), antibodies, ELISA
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Elsevier
ISSN:0022-510X
Deposited On:10 Apr 2017 10:39

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