titoli, abstracts, parole chiave >>>
Immune response induced by Epstein-Barr virus and Mycobacterium avium subsp. paratuberculosis peptides in current and past infectious mononucleosis: a risk for multiple sclerosis?

Mameli, Giuseppe and Madeddu, Giordano and Cossu, Davide and Galleri, Grazia and Manetti, Roberto and Babudieri, Sergio and Mura, Maria Stella Anna and Sechi, Leonardo Antonio (2016) Immune response induced by Epstein-Barr virus and Mycobacterium avium subsp. paratuberculosis peptides in current and past infectious mononucleosis: a risk for multiple sclerosis? European Journal of Neurology, Vol. 23 (1), p. 140-147. ISSN 1468-1331. Article.

Full text not available from this repository.

DOI: 10.1111/ene.12821

Abstract

Background and purpose
Infectious mononucleosis (IM) caused by Epstein–Barr virus (EBV) has been associated with increased risk of multiple sclerosis (MS). However, the mechanism linking these pathologies is unclear. Different reports indicate the association of EBV, and recently Mycobacterium avium subsp. paratuberculosis (MAP), with MS. For a better understanding of the role of these pathogens, the host response induced by selected antigenic peptides in subjects with a history of IM that significantly increases the risk of MS was investigated.
Methods
Both humoral and cell-mediated response against peptides able to induce a specific immune activation in MS patients deriving from lytic and latent EBV antigens BOLF1305−320, EBNA1400−413, from MAP MAP_402718−32, MAP_0106c121−132 and from human proteins IRF5424−434 and MBP85−98 in subjects with current and past IM were examined.
Results
EBNA1 and MAP_0106c peptides were able to induce a humoral immune response in subjects with a history of clinical IM in an independent manner. Moreover, these peptides were capable of inducing pro-inflammatory cytokine interferon γ by CD4+ and CD8+ T lymphocytes and interleukin 6 and tumour necrosis factor α by CD14+ monocyte cells.
Conclusion
Our results highlight that EBV and MAP may be involved independently in the same causal process leading to MS in subjects with a history of IM.

Item Type:Article
ID Code:11329
Status:Published
Refereed:Yes
Uncontrolled Keywords:Antigen-specific T-cell stimulation, cytokines, Epstein–Barr virus, humoral response, infectious mononucleosis, Mycobacterium avium subsp. paratuberculosis
Subjects:Area 05 - Scienze biologiche > BIO/17 Istologia
Area 06 - Scienze mediche > MED/17 Malattie infettive
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:John Wiley & Sons
ISSN:1468-1331
Copyright Holders:© EAN
Deposited On:10 Apr 2017 11:52

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page