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Deep transcranial magnetic stimulation of the dorsolateral prefrontal cortex in alcohol use disorder patients: effects on dopamine transporter availability and alcohol intake

Addolorato, Giovanni and Antonelli, Mariangela and Cocciolillo, Fabrizio and Vassallo, Gabriele A. and Tarli, Claudia and Sestito, Luisa and Mirijello, Antonio and Ferrulli, Anna and Pizzuto, Daniele A. and Camardese, Giovanni and Miceli, Antonio and Diana, Marco and Giordano, Alessandro and Gasbarrini, Antonio and Di Giuda, Daniela (2017) Deep transcranial magnetic stimulation of the dorsolateral prefrontal cortex in alcohol use disorder patients: effects on dopamine transporter availability and alcohol intake. European Neuropsychopharmacology, Vol. 27 (5), p. 450-461. ISSN 0924-977X. Article.

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DOI: 10.1016/j.euroneuro.2017.03.008

Abstract

Repetitive Transcranial Magnetic Stimulation (rTMS) of the dorsolateral prefrontal cortex may affect neuro-adaptations associated with alcohol use disorder (AUD), potentially influencing craving and alcohol intake. We investigated alcohol intake and dopamine transporter (DAT) availability by Single Photon Emission Computed Tomography (SPECT) in the striatum of AUD patients before and after deep rTMS. Fourteen patients underwent baseline clinical and SPECT assessment. Eleven out of fourteen patients were randomized into two groups for the REAL (n.5) or SHAM (n.6) treatment. Clinical and SPECT evaluations were then carried out after four weeks of rTMS sessions (T1). At baseline, AUD patients showed higher striatal DAT availability than healthy control subjects (HC). Patients receiving the REAL stimulation revealed a reduction in DAT availability at T1, whereas the SHAM-treated group did not. In addition, patients receiving the REAL stimulation had a decrease in alcohol intake. The results of this longitudinal pilot study may suggest a modulatory effect of deep rTMS on dopaminergic terminals and a potential clinical efficacy in reducing alcohol intake in AUD patients. Further investigations are required to confirm these preliminary data.

Item Type:Article
ID Code:11316
Status:Published
Refereed:Yes
Uncontrolled Keywords:Alcohol dependence, dopamine transporter, dorsolateral prefrontal cortex, transcranial magnetic stimulation, single photon emission computed tomography, 123I-FP-CIT
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Elsevier
ISSN:0924-977X
Deposited On:19 Sep 2017 09:12

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