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Is there a role for Mycobacterium avium subspecies paratuberculosis in Parkinson's disease?

Arru, Giannina and Caggiu, Elisa and Paulus, Kai Stephan Maria and Sechi, Gianpietro and Mameli, Giuseppe and Sechi, Leonardo Antonio (2016) Is there a role for Mycobacterium avium subspecies paratuberculosis in Parkinson's disease? Journal of Neuroimmunology, Vol. 293 , p. 86-90. ISSN 0165-5728. Article.

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DOI: 10.1016/j.jneuroim.2016.02.016

Abstract

In Parkinson's disease (PD) ZnT proteins play an important role. Zinc is a co-factor of numerous enzymes and stabilizes the tertiary structure of several proteins. Nothing is known about previous infections mediated by Mycobacterium avium subsp. paratuberculosis (MAP). We evaluated if a previous infection with MAP could induce the production of antibodies that cross-reacted with the Znt homologous antigenic peptides associated to Parkinson. The humoral response toward MAP3865c peptides, ZnT3 and ZnT10 was evaluated. The hypothesis of cross-reactivity needs to be confirmed; we have observed the presence of MAP in PD patients by PCR, positivity to MAP3865c peptides, therefore MAP infection but not cross-reaction with human homologous Znt proteins.

Item Type:Article
ID Code:11270
Status:Published
Refereed:Yes
Uncontrolled Keywords:Parkinson's disease, ZnT proteins, autoimmunity, MAP, antigenic peptides
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Elsevier
ISSN:0165-5728
Deposited On:18 Mar 2016 14:00

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