Arru, Giannina and Caggiu, Elisa and Paulus, Kai Stephan Maria and Sechi, Gianpietro and Mameli, Giuseppe and Sechi, Leonardo Antonio (2016) Is there a role for Mycobacterium avium subspecies paratuberculosis in Parkinson's disease? Journal of Neuroimmunology, Vol. 293 , p. 86-90. ISSN 0165-5728. Article.
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In Parkinson's disease (PD) ZnT proteins play an important role. Zinc is a co-factor of numerous enzymes and stabilizes the tertiary structure of several proteins. Nothing is known about previous infections mediated by Mycobacterium avium subsp. paratuberculosis (MAP). We evaluated if a previous infection with MAP could induce the production of antibodies that cross-reacted with the Znt homologous antigenic peptides associated to Parkinson. The humoral response toward MAP3865c peptides, ZnT3 and ZnT10 was evaluated. The hypothesis of cross-reactivity needs to be confirmed; we have observed the presence of MAP in PD patients by PCR, positivity to MAP3865c peptides, therefore MAP infection but not cross-reaction with human homologous Znt proteins.
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