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Determinazione analitica di designer drugs amfetamino simili in matrici complesse

Carta, Antonio (2016) Determinazione analitica di designer drugs amfetamino simili in matrici complesse. Doctoral Thesis.

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Abstract

During these three years of study, the undersigned has dedicated to the validation of three different analytical methods for the identification and quantification of amphetamine-like molecules in three different biological matrices. First of all a screening method has been developed by nuclear magnetic resonance spectroscopy, using electronic reference to access in vivo concentration method (ERETIC).
Subsequently two MRM methods were performed by liquid chromatography electrospray tandem mass spectrometry (LC-(ESI)-MS/MS) for the simultaneous quantification of the cited molecules both in amniotic fluid and in hair. The fast and sensitive analytical methodologies developed would be fundamental to carry out a monitoring phase of the evolution of the drugs black market, and they could be useful in clinic and emergency management, giving a contribution of considerable importance in the field of forensic toxicology.

Item Type:Doctoral Thesis
ID Code:11130
Contributors:Boatto, Gianpiero
Publisher:Universita' degli studi di Sassari
Uncontrolled Keywords:Amfetamine, matrici biologiche, NMR, LC-MS/MS
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Cicli, scuole e corsi:Ciclo 28 > Scienze e tecnologie chimiche > Scienze farmaceutiche
Deposited On:02 May 2016 17:55

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