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Ceria nanoparticles as smart platform for biomedical applications

Pinna, Alessandra (2016) Ceria nanoparticles as smart platform for biomedical applications. Doctoral Thesis.

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Abstract

The present doctoral thesis focuses on the antioxidant activity of cerium oxide nanostructured materials (nanoceria) in biological systems. This goal is obtained through an interdisciplinary approaches spanning from chemistry and physics to biology and medicine. Nanoceria is studied in form of nanoparticles both naked and integrated nanocomposites films. The physicochemical properties are studied by a complete set of characterization techniques such as XRD, FTIR and Raman spectroscopies, DLS, AFM, μ-XRF, SEM and TEM. A specific emphasis is placed on the interactions with cells (PC12, PBMC, oocyte and spermatozoa) as a function of the nanoceria concentration. Different techniques for cell analysis, such as flow cytometry and confocal microscopy, allow monitoring the fate and viability of nanoparticles into the cells.
Our results show that nanoceria can be successfully used as antioxidant agent in biomedical field to improve the cells viability both in physiological condition (IVM) and in Parkinson-like diseases. Moreover, the antioxidant activity of nanoceria is also verified in composite materials for prospected applications as ophthalmic medical devices and smart Petri dishes. These results pave the way to the development of an innovative smart "platform" based on the antioxidant properties of functional nanoceria.

Item Type:Doctoral Thesis
ID Code:11095
Contributors:Malfatti, Luca and Innocenzi, Plinio
Publisher:Universita' degli studi di Sassari
Uncontrolled Keywords:Nanoceria, radicals scavenger, ROS, nanocomposite
Subjects:Area 03 - Scienze chimiche > CHIM/07 Fondamenti chimici delle tecnologie
Area 09 - Ingegneria industriale e dell'informazione > ING-IND/22 Scienza e tecnologia dei materiali
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Cicli, scuole e corsi:Ciclo 28 > Scienze e tecnologie chimiche > Nanochimica, nanomateriali e materiali funzionali
Deposited On:21 Apr 2016 09:05

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