Pinna, Alessandra (2016) Ceria nanoparticles as smart platform for biomedical applications. Doctoral Thesis.
The present doctoral thesis focuses on the antioxidant activity of cerium oxide nanostructured materials (nanoceria) in biological systems. This goal is obtained through an interdisciplinary approaches spanning from chemistry and physics to biology and medicine. Nanoceria is studied in form of nanoparticles both naked and integrated nanocomposites films. The physicochemical properties are studied by a complete set of characterization techniques such as XRD, FTIR and Raman
spectroscopies, DLS, AFM, μ-XRF, SEM and TEM. A specific emphasis is placed on the interactions with cells (PC12, PBMC, oocyte and spermatozoa) as a function of the nanoceria concentration. Different techniques for cell analysis, such as flow cytometry
and confocal microscopy, allow monitoring the fate and viability of nanoparticles into
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