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Ricerca di Microcystin-LR in molluschi bivalvi e nel loro habitat in alcune zone della Sardegna

Sedda, Tiziana (2016) Ricerca di Microcystin-LR in molluschi bivalvi e nel loro habitat in alcune zone della Sardegna. Doctoral Thesis.

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Abstract

Cyanobacterial blooms occur worldwide and present an increasing problem due to eutrophication of aquatic environment. Cyanobacteria produce a wide range of toxins and the most studied and widely distributed are the hepatotoxic microcystins (MCs). They cause morphological and functional changes in hepatocytes by inhibiting the activity of protein phosphatases leading to cell proliferation and cancer or an apoptotic process and cell death. MCs are associated with freshwater environments and their bioaccumulation by aquatic animals, has been reported. Since these organisms are an important food source, MCs can be transferred to higher trophic levels through the food chain leading to human toxicity. The most toxic, abundant and commonly detected cyanotoxin in natural blooms is MC-LR. The health hazards have led the World Health Organization (WHO) to establish a provisional guideline value of MC-LR of 1 g/L in drinking water.
In this work water and bivalves tissues cached in three Sardinian ponds with favourable condition for the development of cyanobacterial blooms have been collected to research and quantify MC-LR. For this purpose enzime linked immunosorbent assay and liquid chromatography-mass spectrometry tecniques were used

Item Type:Doctoral Thesis
ID Code:11068
Contributors:Demontis, Maria Piera
Publisher:Universita' degli studi di Sassari
Uncontrolled Keywords:Microcystin-LR, molluschi
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/07 Farmacologia e tossicologia veterinaria
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Veterinaria
Cicli, scuole e corsi:Ciclo 28 > Scienze veterinarie > Produzione, qualità e sicurezza degli alimenti di origine animale
Deposited On:03 May 2016 12:39

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