titoli, abstracts, parole chiave >>>
Chelation therapy: evaluation of the coordination ability of bis-kojic and hydroxypyridinone derivative ligands towards CdII ions via NMR spectroscopy

Peana, Massimiliano Francesco and Medici, Serenella and Lachowicz, Joanna I. and Nurchi, Valeria Marina and Crisponi, Guido and Puccio, Giuseppe and Zoroddu, Maria Antonietta (2015) Chelation therapy: evaluation of the coordination ability of bis-kojic and hydroxypyridinone derivative ligands towards CdII ions via NMR spectroscopy. In: Cadmium Symposium: ICS 2015: Congress proceedings, June 25-27, 2015, Sassari, Italy. P-15. Conference or Workshop Item.

[img]
Preview
Full text disponibile come PDF Richiede visualizzatore di PDF come GSview, Xpdf o Adobe Acrobat Reader
1534Kb

Abstract

The soft acid CdII is an accumulative toxic metal ion which is able to substitute for the essential borderline ZnII ion in many zinc enzymes. Nuclear magnetic resonance (NMR) spectroscopy was used to assess the coordination ability of two ligands, an amine-bearing bis-kojic acid: 6'-(2-(diethylamino)ethylazanediyl)bis(methylene)bis(5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) [1,2] and a hydroxypiridinone derivative: 5-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one [3], for their use as potential chelating molecules towards CdII ions in detoxification treatments.
A combination of 1D, 2D total correlation spectroscopy (TOCSY), heteronuclear single quantum coherence spectroscopy (HSQC) and rotating-frame Overhauser effect spectroscopy (ROESY) experiments was used to assign the signals of both free and metal-bound ligands, as previously reported for similar systems [4-6]. The metal-ligand system was studied at physiological pH and different temperature values. Competition experiments with essential ZnII ions were also performed.

Item Type:Conference or Workshop Item (Poster)
ID Code:11025
Status:Published
Uncontrolled Keywords:Cadmium, zinc, poisoning therapy, detoxification treatment, chelation
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Deposited On:08 Sep 2015 09:50

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page