Peana, Massimiliano Francesco and Medici, Serenella and Lachowicz, Joanna I. and Nurchi, Valeria Marina and Crisponi, Guido and Puccio, Giuseppe and Zoroddu, Maria Antonietta (2015) Chelation therapy: evaluation of the coordination ability of bis-kojic and hydroxypyridinone derivative ligands towards CdII ions via NMR spectroscopy. In: Cadmium Symposium: ICS 2015: Congress proceedings, June 25-27, 2015, Sassari, Italy. P-15. Conference or Workshop Item.
The soft acid CdII is an accumulative toxic metal ion which is able to substitute for the essential borderline ZnII ion in many zinc enzymes. Nuclear magnetic resonance (NMR) spectroscopy was used to assess the coordination ability of two ligands, an amine-bearing bis-kojic acid: 6'-(2-(diethylamino)ethylazanediyl)bis(methylene)bis(5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) [1,2] and a hydroxypiridinone derivative: 5-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one , for their use as potential chelating molecules towards CdII ions in detoxification treatments.
I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore
Repository Staff Only: item control page