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Association of trace elements with lipid profiles and glycaemic control in patients with type 1 diabetes mellitus in northern Sardinia, Italy: an observational study

Peruzzu, Angela and Solinas, Maria Giuliana and Asara, Yolande and Forte, Giovanni and Bocca, Beatrice and Tolu, Francesco and Malaguarnera, Lucia and Montella, Andrea Costantino Mario and Madeddu, Roberto Beniamino (2015) Association of trace elements with lipid profiles and glycaemic control in patients with type 1 diabetes mellitus in northern Sardinia, Italy: an observational study. Chemosphere, Vol. 132 , p. 101-107. ISSN 0045-6535. Article.

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DOI: 10.1016/j.chemosphere.2015.02.052

Abstract

Sardinia is an Italian region with a high incidence of type 1 diabetes mellitus. This study aimed to determine the associations of trace elements with lipid profiles and glycaemic control in patients with T1DM. A total of 192 patients with T1DM who attended the Unit of Diabetology and Metabolic Diseases in Sassari, Italy, were enrolled. Trace elements zinc, copper, selenium, chromium, and iron were measured in whole blood by sector field inductively coupled plasma mass spectrometry. The correlations between metabolic variables and the levels of trace elements were determined. Zinc was positively correlated with total cholesterol (P = 0.023), low-density lipoprotein (P = 0.0015), and triglycerides (P = 0.027). Iron as significantly correlated with TC (P = 0.0189), LDL (P = 0.0121), and high-density lipoprotein (HDL) (P = 0.0466). In males, Cr was positively correlated with HDL (P = 0.0079) and Se, in females was correlated with TG (P = 0.0113). The mean fasting plasma glucose was166.2 mg dL−1. Chromium was correlated with fasting plasma glucose (P = 0.0149), particularly in males (P = 0.0038). Overall, 63.5% of the patients had moderate HbA1c (7–9%). Copper was significantly correlated with HbA1c% in males (P = 0.0155). In conclusion, the results of this study indicate that trace elements show different associations with lipid levels and glycaemic control in T1DM. Zinc, Fe, and Se were associated with lipid levels whereas Cu and Cr were associated with HbA1c%.

Item Type:Article
ID Code:10997
Status:Published
Refereed:Yes
Uncontrolled Keywords:Type 1 diabetes mellitus (T1DM), trace elements, glycaemic control, lipid profile
Subjects:Area 05 - Scienze biologiche > BIO/17 Istologia
Area 06 - Scienze mediche > MED/01 Statistica medica
Area 05 - Scienze biologiche > BIO/16 Anatomia umana
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > AOU -Azienda Ospedaliero Universitaria, Sassari
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Elsevier
ISSN:0045-6535
Deposited On:10 Jun 2015 12:53

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