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Update of the Phase III trial ‘GRETA’ of surgery and tamoxifen versus tamoxifen alone for early breast cancer in elderly women

Mustacchi, Giorgio and Scanni, Alberto and Capasso, Imma and Farris, Antonio and Pluchinotta, Alfonso and Isola, Giulio (2015) Update of the Phase III trial ‘GRETA’ of surgery and tamoxifen versus tamoxifen alone for early breast cancer in elderly women. Future Oncology, Vol. 11 (6), p. 933-941. ISSN 1479-6694. Article.

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DOI: 10.2217/fon.14.266

Abstract

Background: In the Phase III ‘GRETA’ trial 474 women aged ≥70 years with early breast cancer were randomly assigned to surgery plus tamoxifen for 5 years or tamoxifen alone for 5 years. This is a long-term update.
Patients & methods: Focusing on patients still alive in 2003, outcome end points has been recalculated.
Results: Median distant metastases disease-free survival is longer with tamoxifen alone for 5 years; (48.8 vs 37.9 months; p = 0.009). No difference was found in distant metastases rate, disease-free survival, breast cancer and overall survival.
Conclusion: Primary endocrine treatment until the the best response, followed by minimal surgery and prosecution endocrine treatment for 5–10 years is a suitable option for elderly breast cancer patients. Delayed surgery does not prejudice overall survival.

Item Type:Article
ID Code:10988
Status:Published
Refereed:Yes
Uncontrolled Keywords:Breast cancer, tamoxifen, primary endocrine treatment
Subjects:Area 06 - Scienze mediche > MED/06 Oncologia medica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Future Medicine
ISSN:1479-6694
Deposited On:12 Jun 2015 08:58

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