Sechi, Mario and Azzena, Ugo Gavino and Delussu, Maria Paola and Dallocchio, Roberto and Dessì, Alessandro and Cosseddu, Alessia and Pala, Nicolino and Nouri, Neamati (2008) Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors. Molecules, Vol. 13 (10), p. 2442-2461. ISSN 1420-3049. Article.
HIV-1 integrase (IN) is an attractive and validated target for the development of novel therapeutics against AIDS. In the search for new IN inhibitors, we designed and synthesized three series of bis-amide and hydrazide-containing derivatives of malonic acid. We performed a docking study to investigate the potential interactions of the title compounds with essential amino acids on the IN active site.
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