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Hyperbranched molecular structures with potential antiviral activity: derivatives of 5,6-dihydroxyindole-2-carboxylic acid

Sechi, Mario and Casu, Fabio and Campesi, Ilaria and Fiori, Stefano and Mariani, Alberto (2006) Hyperbranched molecular structures with potential antiviral activity: derivatives of 5,6-dihydroxyindole-2-carboxylic acid. Molecules, Vol. 11 (12), p. 968-977. ISSN 1420-3049. Article.

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DOI: 10.3390/11120968

Abstract

In the search of new HIV-1 integrase (IN) inhibitors, we synthesized a series of multimeric 5,6-dihydroxyindole-2-carboxylic acid (DHICA) derivatives. Preliminary results indicate that hyperbranched architectures could represent a peculiar molecular requisite for the development of new antiviral lead compounds

Item Type:Article
ID Code:1093
Status:Published
Refereed:Yes
Uncontrolled Keywords:Hyperbranched polymers, AB2 monomers, DHICA, HIV-1, antiviral agents
Subjects:Area 03 - Scienze chimiche > CHIM/04 Chimica industriale
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > INSTM-Consorzio Interuniversitario Nazionale per la Scienza e la Tecnologia dei Materiali, Unità di ricerca di Sassari
001 Università di Sassari > 01 Dipartimenti > Chimica
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Molecular Diversity Preservation International
ISSN:1420-3049
Deposited On:18 Aug 2009 10:04

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