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Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells

Datta, Amitabha and Das, Kuheli and Sen, Chandana and Karan, Nirmal Kumar and Huang , Jui-Hsien and Lind, Chia-Her and Garribba, Eugenio and Sinha, Chittaranjan and Askun, Tulin and Celikboyun, Pinar and Mane, Sandeep B. (2015) Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Vol. 148 , p. 427-434. ISSN 1386-1425. Article.

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DOI: 10.1016/j.saa.2015.04.014

Abstract

Doubly end-on azido-bridged mixed-valence trinuclear cobalt complex, [Co3(L)2(N3)6(CH3OH)2] (1) is afforded by employing a potential monoanionic tetradentate-N2O2 Schiff base precursor (2-[{[2-(dimethylamino)ethyl]imino}methyl]-6-methoxyphenol; HL). Single crystal X-ray structure reveals that in 1, the adjacent CoII and CoIII ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis. Complex 1 is subjected on different spectral analysis such as IR, UV—vis, emission and EPR spectroscopy. On variable temperature magnetic study, we observe that during cooling, the χMT values decrease smoothly until 15 K and then reaches to the value 1.56 cm3 K mol−1 at 2 K. Complex 1 inhibits the cell growth on human lung carcinoma (A549 cells), human colorectal (COLO 205 and HT-29 cells), and human heptacellular (PLC5 cells) carcinoma cells. Complex 1 exhibits anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and H37Ra ATCC 25177 strains.

Item Type:Article
ID Code:10890
Status:Published
Refereed:Yes
Uncontrolled Keywords:Co complex, crystal structure, EPR, VTM, inhibitory effect, anti-mycobacterial activity
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Elsevier
ISSN:1386-1425
Deposited On:25 May 2015 10:21

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