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Mycobacterium avium ss. paratuberculosis Zoonosis: the Hundred Year War: beyond Crohn’s disease

Sechi, Leonardo Antonio and Dow, Coad Thomas (2015) Mycobacterium aviumss. paratuberculosis Zoonosis: the Hundred Year War: beyond Crohn’s disease. Frontiers in immunology, Vol. 6 , Article 96. eISSN 1664-3224. Article.

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DOI: 10.3389/fimmu.2015.00096

Abstract

The factitive role of Mycobacterium avium ss. paratuberculosis (MAP) in Crohn’s disease has been debated for more than a century. The controversy is due to the fact that Crohn’s disease is so similar to a disease of MAP-infected ruminant animals, Johne’s disease; and, though MAP can be readily detected in the infected ruminants, it is much more difficult to detect in humans. Molecular techniques that can detect MAP in pathologic Crohn’s specimens as well as dedicated specialty labs successful in culturing MAP from Crohn’s patients have provided strong argument for MAP’s role in Crohn’s disease. Perhaps more incriminating for MAP as a zoonotic agent is the increasing number of diseases with which MAP has been related: Blau syndrome, type 1 diabetes, Hashimoto thyroiditis, and multiple sclerosis. In this article, we debate about genetic susceptibility to mycobacterial infection and human exposure to MAP; moreover, it suggests that molecular mimicry between protein epitopes of MAP and human proteins is a likely bridge between infection and these autoimmune disorders.

Item Type:Article
ID Code:10839
Status:Published
Refereed:Yes
Uncontrolled Keywords:Paratuberculosis, MAP, Crohn’s, autoimmune, molecular mimicry, type 1 diabetes, autoimmune thyroiditis, multiple sclerosis
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Frontiers Research Foundation
eISSN:1664-3224
Deposited On:17 Mar 2015 09:40

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