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Breast cryoablation in patients with bone metastatic breast cancer

Pusceddu, Claudio and Sotgia, Barbara and Amucano, Giovanni and Fele, Rosa Maria and Pilleri, Sara and Meloni, Giovanni Battista and Melis, Luca (2014) Breast cryoablation in patients with bone metastatic breast cancer. Journal of vascular and interventional radiology, Vol. 25 (8), p. 1225-1232. ISSN 1051-0443. eISSN 1535-7732. Article.

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DOI: 10.1016/j.jvir.2014.05.001

Abstract

PURPOSE: To assess retrospectively the safety and feasibility of palliative breast cryoablation to treat primary breast tumors in patients with stage IV breast cancer.
MATERIALS AND METHODS: In 17 female patients (mean age ± SD, 59 y ± 13; range, 37-81 y) with 22 bone metastatic ductal invasive breast lesions (2.5 cm × 1.6 cm ± 1.4 × 1.1; range, 1.0 cm × 0.5 cm to 6.7 cm × 5.5 cm), 19 computed tomography (CT)-guided percutaneous cryoablation sessions were performed for treatment of primary breast tumors. All patients had radiologic evidence (contrast-enhanced CT or magnetic resonance imaging) of persistence or progression of the primary breast cancer despite systemic therapy. The radiologic outcome was evaluated with a mean follow-up period of 13 months (range, 3-31 mo). Treatment of skeletal metastases was unnecessary during the follow-up period.
RESULTS: All of the cryoablation sessions were completed and well tolerated. Complete regression of the disease was achieved in 15 (88%) patients 2 months after the cryoablation. Two (12%) patients underwent a second cryoablation treatment because of a minimal persistence of viable tumor (residual disease). No relapse of primary tumors was observed on breast imaging during the follow-up period. One patient (6%) developed a new lesion localized to the contralateral breast.
CONCLUSIONS: These data suggest that palliative cryoablation of primary advanced breast cancer is a well-tolerated, feasible, and effective treatment option. Given the palliative effects of breast cryoablation demonstrated in this series, larger studies replicating these results are warranted.

Item Type:Article
ID Code:10816
Status:Published
Refereed:Yes
Uncontrolled Keywords:Breast cryoablation, stage IV breast cancer, patients
Subjects:Area 06 - Scienze mediche > MED/36 Diagnostica per immagini e radioterapia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
Publisher:Elsevier
ISSN:1051-0443
eISSN:1535-7732
Deposited On:19 Feb 2015 11:47

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