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Paired neurophysiological and clinical study of the brainstem at different stages of Parkinson’s disease

de Natale, Edoardo Rosario and Ginatempo, Francesca and Paulus, Kai Stephan and Manca, A. and Mercante, Beniamino and Pes, Giovanni Mario and Agnetti, Virgilio and Tolu, Eusebio and Deriu, Franca (2014) Paired neurophysiological and clinical study of the brainstem at different stages of Parkinson’s disease. Clinical neurophysiology , in press. ISSN 1388-2457. eISSN 1872-8952. Article.

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DOI: 10.1016/j.clinph.2014.12.017

Abstract

Objective To study brainstem function in Parkinson’s Disease (PD) at different stages, through a battery of vestibular-evoked myogenic potentials (VEMPs) and compare the results with scores on clinical scales assessing the presence of symptoms linked to brainstem involvement.
Methods Cervical, masseter and ocular VEMPs were recorded in patients with early PD (n = 14, disease duration 1.42 ± 0.7 years), advanced PD (n = 19, disease duration 7.26 ± 2.9 years) and in 27 age-matched controls. In PD, the following clinical scales were administered: Mini-BESTest, REM sleep Behavior Disorder Screening Questionnaire (RBD-SQ), PD Sleep Scale, Epworth Sleepiness Scale and Geriatric Depression Scale.
Results Rate of VEMPs alterations was higher (p < 0.001) in PD than controls, but similar within PD groups. However, early and advanced PD showed a different pattern of abnormalities (p = 0.02), being latency delay prevalent in the former and absence in the latter. VEMP impairment correlated directly with RBD-SQ scores in both PD cohorts and inversely with Mini-BESTest scores in advanced PD.
Conclusions VEMPs displayed progressive severity of alterations at different stages of PD, with remarkable correlations with presence of postural instability and RBD.
Significance The combined use of VEMPs may provide interesting insights into the pathophysiological mechanisms of PD at the earliest and prodromal stage of the disease.

Item Type:Article
ID Code:10812
Status:In Press
Refereed:Yes
Uncontrolled Keywords:Vestibular-evoked myogenic potentials, vestibulo-collic reflex, vestibulo-masseteric reflex, vestibulo-ocular reflex, brainstem, Parkinson’s disease
Subjects:Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Area 05 - Scienze biologiche > BIO/09 Fisiologia
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Elsevier
ISSN:1388-2457
eISSN:1872-8952
Copyright Holders:© 2015 Published by Elsevier Ireland Ltd. on behalf of International Federation of Clinical Neurophysiology
Deposited On:18 Feb 2015 16:12

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